Telomerase activity in ovarian tumors
نویسندگان
چکیده
منابع مشابه
Telomerase activity in gynecological tumors.
Telomerase is a ribonucleoprotein that synthesizes telomeric DNA onto chromosomal ends using an RNA component as a template. Extension of telomeric repeats by telomerase prevents telomere shortening with cell divisions and contributes to chromosomal stability, possibly leading to immortalization of the cells. In the present study, we determined the telomerase activity of gynecological tumors an...
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BACKGROUND The activity of the ribonucleoprotein enzyme telomerase is not detected in normal somatic cells; thus, with each cell division, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode. The current model gaining support is that telomerase activity in germline and immortal cells maintains telomere length and thus compensates for the "end-replication probl...
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Purpose: Telomerase is considered a molecular marker for malignancy. The aim of this study was to determine telomer-ase activity (TA) as a prognostic factor at diagnosis and as a marker for minimal residual disease during therapy and follow up in nonmetastatic Ewing family of tumors (EFT). Patients and Methods: Primary tumor specimens and 97 peripheral blood (PBL) samples from 31 EFT patients w...
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Follicular development is characterized by intensive proliferation and differentiation of granulosa cells. It was reported that during follicular growth granulosa cells arise from the population of stem cells. One of the main evidences for stem characteristics of the cell is the ability to express telomerase--an enzyme complex responsible for integrity and stability of chromosome ends (telomere...
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Telomerase, the enzyme that stabilizes telomere length is reactivated with almost all cancer types, and may be a useful diagnostic marker for malignancy. Telomerase activity has been detected in germ line cells and most cancer cells, whereas most normal somatic cells have no clearly detectable telomerase activity. In our study, we aim to detect telomerase activity in 20 human central nervous sy...
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ژورنال
عنوان ژورنال: Cancer
سال: 1997
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19970915)80:6<1085::aid-cncr11>3.0.co;2-4